The hypothalamus, as it explains to “EL MUNDO” the investigator Miguel Lopez, of the University of Santiago de Compostela, is a ” very primitive zone of the brain “, very armored along the evolution because it is the manager of regulating basic survival mechanisms, as the regulation of the balance sheet of energy: The balance between the calories that we consume and that we burn.
Since in 1994 there was discovered the “leptima” (a hormone that disables the food ingestion), many investigations have looked in the mechanisms of the hypothalamus on which to be able to act to influence our appetite and to be able to modify the risk of obesity. In this occasion, one of these pieces of this complex puzzle has been found by investigators of the University Jhns Hopkins (EEUU), thanks to the experiments with mice done to the team of Richard Huganir and Olof Lagerlöf.
It’s a new role of the OGT enzyme that, they are blocked the little zone of the hypothalamus of the mice, that it make a increase of weight in three weeks. In fact, without the act of the OGT enzyme for to control the appetite and the sensation of satiety, in just 20 days, the animals gets to triple the levels of corporal fat.
Although it received food the same time of other mice, the animals without this cerebral enzyme remain more time eating and ingest more calories at times. For other side, if there restricted the access to the food, the animals didn’t get weight. The authors determinate that without the OGT enzyme the mice can’t be satiety